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Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice
CONCLUSIONS: These results provide insights into the central role of NLRP3-caspase-1 pyroptotic innate immune signaling and loss of lung endothelial adherens junctions in the mechanism of acute respiratory distress syndrome induced by SARS-CoV-2. Our data show that treatment with IL-1RA during activation of inflammasome provides the ideal scenario for preventing lung vascular injury and respiratory failure in coronavirus disease 2019 (COVID-19).PMID:34496633 | DOI:10.1161/ATVBAHA.121.316925
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 9, 2021 Category: Cardiology Authors: Shiqin Xiong Lianghui Zhang Justin M Richner Jake Class Jalees Rehman Asrar B Malik Source Type: research

SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells.
Abstract Currently, the world is suffering from the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that uses angiotensin-converting enzyme 2 (ACE2) as a receptor to enter the host cells. So far, 30 million people have been infected with SARS-CoV-2, and nearly 1 million people have died because of COVID-19 worldwide, causing serious health, economical, and sociological problems. However, the mechanism of the effect of SARS-CoV-2 on human host cells has not been defined. The present study reports that the SARS-CoV-2 spike protein alone without ...
Source: Vascular Pharmacology - November 21, 2020 Category: Drugs & Pharmacology Authors: Suzuki YJ, Nikolaienko SI, Dibrova VA, Dibrova YV, Vasylyk VM, Novikov MY, Shults NV, Gychka SG Tags: Vascul Pharmacol Source Type: research

The impact of the SARS-CoV-2 epidemic outbreak on the vascular access team operations after conversion to COVID-19 dedicated hospital
CONCLUSIONS: The experience we gained will allow us to be more prepared in the future and our experience has highlighted that a structured Vascular Access Team is necessary to respond adequately to COVID-19 patients' needs, to ensure the effectiveness of the maneuver, to reduce complications and to avoid the waste of resources, always working in safe condition.PMID:33827318 | DOI:10.1177/11297298211005254
Source: The Journal of Vascular Access - April 8, 2021 Category: Surgery Authors: Elisa Deganello Francesco Gastaldo Sonia Masiero Milena Fasson Riccardo Ivan Colopi Luciano Girotto Jacopo Monticelli Elena Marcante Patrizia Furlan Vincenzo Baldo Claudio Pilerci Piero Realdon Domenico Montemurro Alberto Rigo Patrizia Benini Fabio Baratt Source Type: research

Correction to: Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice
Arterioscler Thromb Vasc Biol. 2023 May;43(5):e171. doi: 10.1161/ATV.0000000000000162. Epub 2023 Apr 26.NO ABSTRACTPMID:37099642 | DOI:10.1161/ATV.0000000000000162
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 26, 2023 Category: Cardiology Source Type: research